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・ Lymphocytic interstitial pneumonia
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Lymphokine-activated killer cell
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Lymphokine-activated killer cell : ウィキペディア英語版
Lymphokine-activated killer cell
In cell biology, a lymphokine-activated killer cell (also known as a LAK cell) is a white blood cell that has been stimulated to kill tumor cells.〔(【引用サイトリンク】 title=Definition of lymphokine-activated killer cell )〕 If lymphocytes are cultured in the presence of Interleukin 2, it results in the development of effector cells which are cytotoxic to tumor cells.〔(【引用サイトリンク】 title=Medical Dictionary: Lymphokine-activated killer cell )
==Mechanism==
It has been shown that lymphocytes, when exposed to Interleukin 2, are capable of lysing fresh, non-cultured cancer cells, both primary and metastatic. LAK cells respond to these lymphokines, particularly IL-2, by lysing tumor cells that were already known to be resistant to NK cell activity.
The mechanism of LAK cells is distinctive from that of natural killer cells because they can lyse cells that NK cells cannot.〔 LAK cells are also capable of acting against cells that do not display the major histocompatibility complex, as has been shown by the ability to cause lysis in non-immunogenic, allogeneic and syngeneic tumors.〔 LAK cells are specific to tumor cells and do not display activity against normal cells.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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